Dhar Lab
  • Home
  • Science
  • Teaching
  • Publications
  • Talks
  • Team
  • Employment
  • Education
  • Personal
  • Contact

PUBLICATIONS

Nature India articles
(commentary, opinion, features)

25. The dark matter of genome
Nature India, Jan 2013
Pawan K.Dhar

24. Will recombinant DNA technology 
become obsolete?
Nature India, Dec 2012
Pawan K. Dhar

23. Science and Spirituality - soul searching
Nature India, Oct 2012
Pawan K. Dhar

22. Science and Spirituality - explaining evolution
Nature India, Aug 2012
Pawan K. Dhar

21. Science and Spirituality - analysing illusions
Nature India, July 2012
Pawan K. Dhar

20. Science and Spirituality - decoding nothingness
Nature India, June 2012
Pawan K. Dhar

19. Science and Spirituality
Nature India, May 2012
Pawan K. Dhar

18. Virtual Cell: computing human brain
Nature India, April 2012
Pawan K. Dhar

17. Virtual cell: computing human skin
Nature India, Mar 2012
Pawan K. Dhar

16. Virtual Cell: Making a virtual human liver
Nature India, Feb 2012
Pawan K. Dhar

15. Virtual Cell: Making a virtual heart
Nature India, Jan 2012
Pawan K. Dhar

14. Virtual cell: Making tiny life forms
Nature India, Dec. 2011
Pawan K. Dhar

13. Virtual Cell: How to make one
Nature India, Nov 2011
Pawan K Dhar

12. Virtual Cell
Nature India, Oct. 2011
Pawan K. Dhar

11.In-vitro meat
Nature India, Sept. 2011
Pawan K.Dhar

10. Hacking the genetic code
Nature India, Aug 2011
Pawan K Dhar

9. What's ailing our lungs?
Nature India, July 2011
Pawan K Dhar

8. Shape me up DNA
Nature India, June 2011
Pawan K Dhar

7. A periodic table for biology
Nature India, May 2011
Pawan K Dhar

6. Making a genome
Nature India, April 2011
Pawan K Dhar

5. Finding new laws in biology
Nature India, Mar 2011 
Pawan K Dhar


4. Biology by design 
Nature India, Feb 2011
Pawan K Dhar
 


3. Zincing towards genome engineering
Nature India Jan 2011 
Pawan K Dhar

2. 'Promoting' DNA once again

Nature India Dec 2010
Pawan K Dhar


1. The Language of Life  
Nature India Oct. 2010
Pawan K Dhar
​

What community says 
about our work ...

"The non-coding protein paper is a potentially ground breaking work..." European Science Commission, March 2010  official report

Cellware tool chosen as 12 best platforms 
among >110 computational systems biology 
platforms available in 2006.  
Nature Biotechnology paper 

Press coverage


Jun 2013    Indian Express
Mar 2012    Biospectrum India
Dec 2010   PharmaBiz article
Oct 2010    Biodesign India 1.0
Jun 2010    Express Buzz
Dec 2002   Strait times, Singapore





 

 
PATENTS

1. Apr 28, 2016   Ref: 201611014807 (Indian Patent Office)
    July 19, 2016 PCT/IB2016/054294 (International Patent)
    METHOD OF DATA COMPRESSION AND DECOMPRESSION
    Girik MALIK, and  Pawan K. DHAR, 
    Agent: SS Rana, New Delhi

2. Oct. 16, 2015          Ref: PCT/IB2015/057964 (US Patent office)
    A BIOMOLECULE BASED DATA STORAGE SYSTEM
    Girik MALIK and Pawan K. DHAR
    Agent: SS Rana, New Delhi


PUBLICATIONS IN SYNTHETIC BIOLOGY

19. Singh V, Braddick D, Dhar PK. Exploring the potential of genome editing CRISPR-Cas9 technology.
​      Gene. 2017: 599, 1-18.

18. Joshi K, Goyal S, Grover S, Jamal S, Singh A, Dhar P, Grover A. Novel group-based QSAR and combinatorial
      design of CK-1δ inhibitors as neuroprotective agents.
BMC Bioinformatics. 2016: 17(Suppl 19):515. 

17, Pawan K. Dhar, Satya Prakash Dash, Deepak Singh. Synthetic Biology and the responsible futures.
      BioVoice 2016: 2, 28-30  [click here to download the article]

16. Systems and Synthetic Biology (Springer, 2015)
      Top 25% downloaded eBook in 2015 (Springer stats)  
      Singh Vikram, Pawan K Dhar eds.


15.  Varughese D, AS. Nair, PK. Dhar. Function Annotation of Novel Peptides Generated from the non-
       expressing genome of Drosophila melanogaster
. Bioinformation 2017: 13(1):17-20.

14.  P.R.Shidhi, Prashanth Suravajhala, Aysha Nayeema, Achuthsankar S. Nair, Shailja Singh and Pawan K. Dhar.
       Making novel proteins from pseudogenes. Bioinformatics. 2015: 31(1):33-9.

13.  Navya Raj, Agnes Helen, N. Manoj, Harish G., Vipin Thomas, Shailja Singh, Seema Sehrawat, Shaguna Seth,
       Achuthsankar S. Nair, Pawan K. Dhar. In silico study of peptide inhibitors against BACE 1. Sys. Synth.
       Biol. J. 2015 9: 67-72

12.  Krishnan R, Vinod Kumar, Vivek Ananth, Shailja Singh, Achuthsankar S. Nair, Pawan K. Dhar. Computational
       identification of novel microRNAs and their targets in the malarial vector. Anopheles stephensi.
       
Sys & Synth.Biol J 2015: 9: 11-7.

11. Singh D and PK Dhar. Exploring the Future of Synthetic Biology in India and its Probable Pathways from
       Infancy to Maturity.
Curr Synthetic Sys Biol 2013, 1: 106 

10.  Singh, V, I. Mani, DK Chaudhary, PK Dhar. Metabolic Engineering of Biosynthetic Pathway for Production
        of Renewable Biofuels
. Appl Biochem Biotechnol 2014: 172, 1158-1171

9.    Joshi M, SV Kundapura, T Poovaiah, K Ingle, PK Dhar. Discovering Novel Anti-Malarial peptides from the
       Not-coding Genome - A Working Hypothesis.
Curr Synth Sys Biol  2013, 1:1  

8.   Dhar PK. Synthetic biology and biomediated synthesis of organic chemicals. In the “Impact of scientific
      developments on the chemical weapons convention” IUPAC technical report. Smallwood K, Trapp R, Mathews
       R, Schmidt B, Sydnes LK (2013)

7.  Dhar PK. Will recombinant DNA technology become obsolete? Nature India, Dec 2012

6.   Dhar PK (2011): Emerging trends in synthetic biology. In the “Trends in Science and Technology Relevant to
       the Biological & Toxin Weapons Convention”. US National Academies of Sciences. ISBN-13:978-0-309-20929-8

5.   Dhar PK (2010): Synthetic Biology in India and Japan. In the “Synthetic Biology from Science to Governance”
      European Science Commission meeting, Brussels. The report described our work “potentially groundbreaking”

4.  Dhar PK. Hacking the genetic code. Nature India, Aug 2011

3.  Dhar PK. Making a genome. Nature India, April 2011

2.   Krishnan R et al. Building momentum for systems and synthetic biology in India. Sys Syn Biol. 2010:
​      4, 237-40

1.  Dhar PK et al. Synthesizing non-natural parts from natural genomic template. J. Biol. Engg.  2009: 3, 2  


PUBLICATIONS IN SYSTEMS BIOLOGY AND BIOINFORMATICS
 

38. Krishnan R, AS Nair, Pawan K Dhar. Computational study of HUB microRNA in human cardiac diseases.
      Bioinformation 2017: 13, 17-20.

37. Kopal Joshi, Sukriti Goyal, Sonam Grover, Salma Jamal, Aditi Singh, Pawan Dhar and Abhinav Grover
       Novel group-based QSAR and combinatorial design of CK-1δ inhibitors as neuroprotective agents.
       BMC Bioinformatics 2016 (accepted)

36.  Dhar PK. Converting Life into numbers. IJCB 0007:98-99, 2012
 
35.  Namboodiri S, A Giuliani, PK Dhar (2012): Looking for a sequence based allostery definition: a statistical
       journey at different resolution scales
. J. Theor. Biol 304:211-8  

34.  Dhar PK. Virtual Cell: computing human brain. Nature India, April 2012

33.  Dhar PK: Virtual cell: computing human skin. Nature India, Mar 2012

32.  Dhar PK. Virtual Cell: Making a virtual human liver. Nature India, Feb 2012

31.  Dhar PK. Virtual Cell: Making a virtual heart. Nature India, Jan 2012

30.  Dhar PK. Virtual cell: Making tiny life forms. Nature India, Dec. 2011

29.  Dhar PK. Virtual Cell: How to make one. Nature India, Nov 2011

28.  Dhar PK. Virtual Cell. Nature India, Oct. 2011

27.  Aswathi BL,  AS Nair, A Sivasankaran, PK Dhar (2011): Identification of hub proteins from sequence.
        Bioinformation 7,163-8 
 
26.  Tun K, Menghini M, Dhar PK, Tanaka H, Giuliani A (2011): Why so few drug targets: a mathematical
       explanation. 
Current Computer-Aided Drug Design 7, 206-213  
 
25.  Dhar PK (2011): A periodic table for biology. Nature India, May 2011.
 
24.  Dhar PK (2011): Finding new laws in biology. Nature India, Mar 2011 
 
23.  Krishnan R, Manjaly-Antony LA, PK Dhar (2010): Building momentum for systems and synthetic biology in
       India
. 
Sys. Synth. Biol. 4, 237-40.  
 
22.  Namboodiri S, Verma C, Dhar PK, Giuliani A, Nair AS (2010): Sequence signatures of allosteric proteins
        towards rational design . Sys. Synth. Biol 2010: 4(4):271-80   
 
21.  Dhar PK, A.Giuliani. Laws in Biology: why so few ? Sys. Synth. Biol 2010: 4, 7-13  

20.  Rao R, K. Tun, Y. Makita, PK Dhar (2009): Amino-acid Residue Association models for large scale protein-
        protein interaction prediction
In Silico Biol 2009: 9, 0015  

19.  Tun K, Raghuraj Rao, L Swamedham, PK Dhar (2009): Rich can get poor – an evolutionary study of hub
        proteins.
 Sys. Synth. Biol. 2009: 2, 75-82  

18.  Dhar PK (2007): The next step in biology: A periodic table? J. of Biosciences, 2007: 2, 1005-8  

17.  Dhar PK, R. Weiss (2006): Enabling the new biology of 21st century. Sys. Synth. Biol 1(1), 1-2  

16. Tun K, PK Dhar, MC Palumbo, A. Giuliani (2006): Metabolic Pathways Variability and Sequence / Networks
       Comparisons.
BMC Bioinformatics 7, 24  

15. Palumbo MC, A Colosimo, K Tun, PK Dhar, A Giuliani (2006): Networks Everywhere? Some general
       implications of an emergent metaphor.
Current Bioinformatics 1, 219-234  

14. Mondry A, Z.Wang, P.K.Dhar (2005): Bone and the kidney: A systems biology approach to the molecular
       mechanisms of renal osteodystrophy .
Curr Mol Med  5, 489-496  

13.  Dhar PK (2005):  Systems Biology is all noise. Current Science 88, 1022-23  

12.  Zhu H, Yinghui Wu, Sui Huang, Yan Sun, Pawan Dhar (2005): Cellular Automata With Object-Oriented
       Features For Parallel Molecular Network Modeling.
IEEE Transactions in NanoBioscience 2005: 4, 141-148   

11.  Dhar PK, Tan Chee Meng et al  (2005): Grid Cellware - The first grid enabled Tool for Modeling And
       Simulating cellular processes
. Bioinformatics 21, 1284-7  

10.  S. Arjun, Pawan Dhar, Masaru Tomita (2005): E-Cell System : Basic concepts and applications
       Kluwer Academic Publishers & Landes Biosciences. USA. 

09.  Zhu H, Sun Yan, G.Rajagopal, A.Mondry, Pawan Dhar (2004): Facilitating arrhythmia simulation: the method
       of quantitative cellular automata modeling and parallel running
. BioMedical Engineering OnLine 3, 29: 1-15  

08.  Zhu H, Peter Pang, Yan Sun and Pawan Dhar (2004): Asynchronous Adaptive Time Step In Quantitative
       Cellular Automata Modeling.
BMC Bioinformatics 5, 1-7  

07.  Dhar P (2004): Application of grid technology in systems biology: parameter estimation. IEEE
       Proceedings, BioGrid, Japan

06.  Rizwan A, Arun Krishnan, Pawan Dhar (2004): A Parallel Implementation of Gillespie's Direct Method.
       Lecture Notes in Computer Science series 3037, 284-291 

05.  Dhar PK, Zhu Hao, Santosh Mishra (2004): Computational approach to systems biology: from fraction to
       integration and beyond.
IEEE Transactions on Nano-Bioscience 3, 144-152  

04.  Dhar PK, TC Meng,S Somani, Li Ye, A Sairam, M Chitre, Z Hao, K Sakharkar. Cellware – a new modeling and
       simulation tool for Computational Systems Biology.
Bioinformatics 2004: 20, 1319-1321   Covered by “The
       Scientist” magazine, July 05, 2004  

03.  Meng TC, Sandeep Somani, Pawan Dhar (2004) Modeling and simulation of biological systems with
        stochasticity.
 In Silico Biology 2004: 4, 0024.  

02.  Hao Z, Sui Huang, Pawan Dhar (2003): The next step in Systems Biology: Simulating temporo-spatial
       dynamics of the molecular networks.
BioEssays 26, 68-72.  

01.  Hashimoto K, Sae Seno, Pawan Dhar, M.Tomita (2002):  Integrative modeling of gene expression and
        metabolismin a cell.
Artificial Life and Robotics 6: 99-107.
 

PUBLICATIONS IN GENETICS AND MOLECULAR BIOLOGY

26.  Manvati S, KC Mangalhar, J Khan, , GL Pathania, S Kaul, M Kaushik, A Arora, PK. Dhar. Deciphering the role
       of microRNA – A step by step guide. Gene Expression Patterns (accepted) 2017


25.  Das P, Dlleepkumar R, AS Krishnan, AS Nair, PK Dhar, Oommen OV. Decahydroquinolines from the venom
       of a formicinae ant, Oecophylla smaragdina. Toxicon 2014: 92, 50-3.

24. Dhar PK. The dark matter of genome. Nature India, Jan 2013

23.  Kumari U, PK Dhar, UM Dhanalekshmi, GK Bhat (2013): Fibroadenoma and breast cancer patients’
       lymphocytes sensitivity to gamma rays- An evaluation by micronuclei assay. Annals of Biological Research 
       4, 148-156.

22.  Kumari U, PK Dhar, UM Dhanalekshmi, GK Bhat (2013): Significance of silver stained nucleolar organizer
       regions in benign breast diseases and breast cancer. Archives of Applied Science Research 5, 60-68.

21.  Dhar PK. Will recombinant DNA technology become obsolete? Nature India, Dec 2012

20.  Dhar PK. What's ailing our lungs? Nature India, July 2011

19.  Dhar PK. Shape me up DNA.Nature India, June 2011

18.  Dhar PK. Zincing towards genome engineering. Nature India Jan 2011

17.  Dhar PK. 'Promoting' DNA once again. Nature India Dec 2010

16.  Dhar PK. The Language of Life. Nature India Oct. 2010

15. Sakharkar KR, Pawan K. Dhar and Vincent T.K. Chow (2004): Genome reduction in prokaryotic obligatory
       intracellular parasites of humans – a comparative analysis. Int J Syst Evol Microbiol 54, 1937 – 41.  

14. Sonoda E, Zhao GY, Kohzaki M, Dhar PK, Kikuchi K, Redon C, Pilch DR, Bonner WM, et al (2007): Collaborative
       roles of gamma H2AX and Rad51 paralog Xrcc3 in homologous recombinational repair. DNA Repair  6,280-92. 

13. Dhar PK (2004): The Cell equator - more than poles apart. Trends in Biotechnology 22, 103-4  

12. Dhar PK, E.Sonoda, A.Fujimori, Y.M.Yamashita, S Takeda (2001): Experimental evidence in support of chicken
       DT40 cell line as a unique model for DNA repair studies. Journal of Environ. Path and Toxicol, USA 20:273-283.  

11. Fukushima T, M.Takata, C.Morrison, R.Araki, A.Fujimori, M.Abe, K.Tatsumi, M.Jasin, P.K.Dhar et al  (2001):
      Genetic analysis of the DNA dependent protein kinase reveals an inhibitory role of Ku in late G2 phase DNA
      double strand break repair. JBC 276 (48), 44413-8.  

10. Fujimori A, S.Tachiri, E.Sonoda, L.H.Thompson, Pawan K. Dhar, M.Hiraoka, S.Takeda et al (2001): Rad52
       partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells.
       EMBO J 20, 5513-5520.  

09. Dhar Pawan K, A.Kryscio, C.Streffer (2000): Application of FISH technique in normal, transformed and
       malignant cell lines using alpha pan centromeric DNA probes. Current Sci 78, 1247-49.  

08.  Dhar PK (2000): Mammalian cloning – an evolutionary perspective. Current Sci. 78, 102.

07.  Dhar PK, Rao TR, Sreekumaran Nair N, Mohan S, Chandra S, Bhat KR, Rao K (2000): Identification of risk
        factors for specific subsites within the oral and oropharyngeal region—a study of 647 cancer patients. Ind J
        Cancer 37(2-3),114-22.

06.   Dhar P K, Y Kumar (2000): GenSoft 2000 -  A new software for diagnosing genetic diseases. Ind J Human
        Genet 5(1), 67-68.

05.   Dhar PK, T.R.Rao, U.Harischandran, K.R.Bhat (1999): Diagnostic importance of nuclear morphometry in oral
        cancers. Ind J. Orofacial Genetics 2 (2); 15-21.

04.   Dhar Pawan K (1999): Oral DNA vaccines – The start of the art. Ind J Orofacial Genet 1, 11-4

03.   Dhar Pawan K, S.Devi., et al (1996): Significance of Lymphocyte Sister Chromatid Exchanges in Ovarian
        Cancer patients . Cancer Genet & Cytogenet 89(2); 105-108.  

02.   Dhar  PK, MR Kumar, S Nayak, et al 91995): A rapid staining and destaining technique for silver nucleolus    
         organizer regions. Biotechnic and Histochemistry. 70(6); 302-30.  

01.   Bamezai R, Bhattacharya V, Husain SA, Dhar P K (1989): Genetics of non-syndromic cleft lip and palate - A five
        year study. DAE proceedings on Human Genetics  10, 55-60. 
​

BOOKS

11. E-Cell System : Basic concepts and applications
Kluwer Academic Publishers & Landes Biosciences. USA.
S. Arjun, Pawan Dhar, Masaru Tomita (2005)
 
10. Textbook of Biochemistry
Jay Pee Brothers Medical Publishers, New Delhi, (1998).
Vasudevan DM, Sreekumari, S, Dhar Pawan, Bhat PG
 
9. Human Genetics
Jay Pee Brothers Medical Publishers, New Delhi, (1997).
Dhar Pawan
 
8. Latest Concepts in Medical Genetics
KMC Press, Manipal, India, (1995)
Dhar Pawan
 
CHAPTERS 

7. Modeling Spatiotemporal Dynamics of Multicellular signaling
Book chapter in: Introduction to Systems Biology Editor: Sandun Choi, Caltech
Humana Press, USA, 2007
Hao Zhu, Pawan Dhar

6. Computer Aided Design of Signaling Networks
Book chapter in: Information processing and living systems. Vladmir Bajic Eds.
World Scientific Press (2005)
Zhu Hao, Pawan Dhar
 
5. Electronic Cell Environments: Combining Gene, Protein and Metabolic Networks
Book Chapter in: Complex Systems Science in Biomedicine.  Deisboeck TS, Yasha
Kresh J, Kepler TB Eds. (2003) Kluwer Academic Publishers, New York.
Pawan Dhar, Masaru Tomita
 
4. E- Cell: Computer simulation of Electronic Cell
Book chapter in: Encyclopedia of Molecular cell biology and Molecula Medicine.
Robert A Myers Eds.WILEY-VCH Verlag, GmbH & Co (2003)
Pawan Dhar, Kouichi Takahashi, Yoichi Nakayama, Masaru Tomita
 
3. Medical Genetics Questions
Exam Master Corporation, Delaware, USA. (Electronic publication), (2000)
Dhar Pawan
 
2. Human Genetics
Book chapter in: Textbook of Pedodontics
Tandon S Eds. Paras Medical Publishers. Hyderabad., India, (2001)
Dhar Pawan

1.Career in Human Genetics
Book chapter in: Specialty selection guide.
Fact Find Eds. MAHE Publications. Manipal, India (2000)
Dhar Pawan
Powered by Create your own unique website with customizable templates.