PUBLICATIONS
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Nature India articles
(commentary, opinion, features) 25. The dark matter of genome Nature India, Jan 2013 Pawan K.Dhar 24. Will recombinant DNA technology become obsolete? Nature India, Dec 2012 Pawan K. Dhar 23. Science and Spirituality - soul searching Nature India, Oct 2012 Pawan K. Dhar 22. Science and Spirituality - explaining evolution Nature India, Aug 2012 Pawan K. Dhar 21. Science and Spirituality - analysing illusions Nature India, July 2012 Pawan K. Dhar 20. Science and Spirituality - decoding nothingness Nature India, June 2012 Pawan K. Dhar 19. Science and Spirituality Nature India, May 2012 Pawan K. Dhar 18. Virtual Cell: computing human brain Nature India, April 2012 Pawan K. Dhar 17. Virtual cell: computing human skin Nature India, Mar 2012 Pawan K. Dhar 16. Virtual Cell: Making a virtual human liver Nature India, Feb 2012 Pawan K. Dhar 15. Virtual Cell: Making a virtual heart Nature India, Jan 2012 Pawan K. Dhar 14. Virtual cell: Making tiny life forms Nature India, Dec. 2011 Pawan K. Dhar 13. Virtual Cell: How to make one Nature India, Nov 2011 Pawan K Dhar 12. Virtual Cell Nature India, Oct. 2011 Pawan K. Dhar 11.In-vitro meat Nature India, Sept. 2011 Pawan K.Dhar 10. Hacking the genetic code Nature India, Aug 2011 Pawan K Dhar 9. What's ailing our lungs? Nature India, July 2011 Pawan K Dhar 8. Shape me up DNA Nature India, June 2011 Pawan K Dhar 7. A periodic table for biology Nature India, May 2011 Pawan K Dhar 6. Making a genome Nature India, April 2011 Pawan K Dhar 5. Finding new laws in biology Nature India, Mar 2011 Pawan K Dhar 4. Biology by design Nature India, Feb 2011 Pawan K Dhar 3. Zincing towards genome engineering Nature India Jan 2011 Pawan K Dhar 2. 'Promoting' DNA once again Nature India Dec 2010 Pawan K Dhar 1. The Language of Life Nature India Oct. 2010 Pawan K Dhar
What community says about our work ... "The non-coding protein paper is a potentially ground breaking work..." European Science Commission, March 2010 official report Cellware tool chosen as 12 best platforms among >110 computational systems biology platforms available in 2006. Nature Biotechnology paper Press coverage Jun 2013 Indian Express Mar 2012 Biospectrum India Dec 2010 PharmaBiz article Oct 2010 Biodesign India 1.0 Jun 2010 Express Buzz Dec 2002 Strait times, Singapore |
PATENTS
1. Apr 28, 2016 Ref: 201611014807 (Indian Patent Office) July 19, 2016 PCT/IB2016/054294 (International Patent) METHOD OF DATA COMPRESSION AND DECOMPRESSION Girik MALIK, and Pawan K. DHAR, Agent: SS Rana, New Delhi 2. Oct. 16, 2015 Ref: PCT/IB2015/057964 (US Patent office) A BIOMOLECULE BASED DATA STORAGE SYSTEM Girik MALIK and Pawan K. DHAR Agent: SS Rana, New Delhi PUBLICATIONS IN SYNTHETIC BIOLOGY 19. Singh V, Braddick D, Dhar PK. Exploring the potential of genome editing CRISPR-Cas9 technology. Gene. 2017: 599, 1-18. 18. Joshi K, Goyal S, Grover S, Jamal S, Singh A, Dhar P, Grover A. Novel group-based QSAR and combinatorial design of CK-1δ inhibitors as neuroprotective agents. BMC Bioinformatics. 2016: 17(Suppl 19):515. 17, Pawan K. Dhar, Satya Prakash Dash, Deepak Singh. Synthetic Biology and the responsible futures. BioVoice 2016: 2, 28-30 [click here to download the article] 16. Systems and Synthetic Biology (Springer, 2015) Top 25% downloaded eBook in 2015 (Springer stats) Singh Vikram, Pawan K Dhar eds. 15. Varughese D, AS. Nair, PK. Dhar. Function Annotation of Novel Peptides Generated from the non- expressing genome of Drosophila melanogaster. Bioinformation 2017: 13(1):17-20. 14. P.R.Shidhi, Prashanth Suravajhala, Aysha Nayeema, Achuthsankar S. Nair, Shailja Singh and Pawan K. Dhar. Making novel proteins from pseudogenes. Bioinformatics. 2015: 31(1):33-9. 13. Navya Raj, Agnes Helen, N. Manoj, Harish G., Vipin Thomas, Shailja Singh, Seema Sehrawat, Shaguna Seth, Achuthsankar S. Nair, Pawan K. Dhar. In silico study of peptide inhibitors against BACE 1. Sys. Synth. Biol. J. 2015 9: 67-72 12. Krishnan R, Vinod Kumar, Vivek Ananth, Shailja Singh, Achuthsankar S. Nair, Pawan K. Dhar. Computational identification of novel microRNAs and their targets in the malarial vector. Anopheles stephensi. Sys & Synth.Biol J 2015: 9: 11-7. 11. Singh D and PK Dhar. Exploring the Future of Synthetic Biology in India and its Probable Pathways from Infancy to Maturity. Curr Synthetic Sys Biol 2013, 1: 106 10. Singh, V, I. Mani, DK Chaudhary, PK Dhar. Metabolic Engineering of Biosynthetic Pathway for Production of Renewable Biofuels. Appl Biochem Biotechnol 2014: 172, 1158-1171 9. Joshi M, SV Kundapura, T Poovaiah, K Ingle, PK Dhar. Discovering Novel Anti-Malarial peptides from the Not-coding Genome - A Working Hypothesis. Curr Synth Sys Biol 2013, 1:1 8. Dhar PK. Synthetic biology and biomediated synthesis of organic chemicals. In the “Impact of scientific developments on the chemical weapons convention” IUPAC technical report. Smallwood K, Trapp R, Mathews R, Schmidt B, Sydnes LK (2013) 7. Dhar PK. Will recombinant DNA technology become obsolete? Nature India, Dec 2012 6. Dhar PK (2011): Emerging trends in synthetic biology. In the “Trends in Science and Technology Relevant to the Biological & Toxin Weapons Convention”. US National Academies of Sciences. ISBN-13:978-0-309-20929-8 5. Dhar PK (2010): Synthetic Biology in India and Japan. In the “Synthetic Biology from Science to Governance” European Science Commission meeting, Brussels. The report described our work “potentially groundbreaking” 4. Dhar PK. Hacking the genetic code. Nature India, Aug 2011 3. Dhar PK. Making a genome. Nature India, April 2011 2. Krishnan R et al. Building momentum for systems and synthetic biology in India. Sys Syn Biol. 2010: 4, 237-40 1. Dhar PK et al. Synthesizing non-natural parts from natural genomic template. J. Biol. Engg. 2009: 3, 2 PUBLICATIONS IN SYSTEMS BIOLOGY AND BIOINFORMATICS 38. Krishnan R, AS Nair, Pawan K Dhar. Computational study of HUB microRNA in human cardiac diseases. Bioinformation 2017: 13, 17-20. 37. Kopal Joshi, Sukriti Goyal, Sonam Grover, Salma Jamal, Aditi Singh, Pawan Dhar and Abhinav Grover Novel group-based QSAR and combinatorial design of CK-1δ inhibitors as neuroprotective agents. BMC Bioinformatics 2016 (accepted) 36. Dhar PK. Converting Life into numbers. IJCB 0007:98-99, 2012 35. Namboodiri S, A Giuliani, PK Dhar (2012): Looking for a sequence based allostery definition: a statistical journey at different resolution scales. J. Theor. Biol 304:211-8 34. Dhar PK. Virtual Cell: computing human brain. Nature India, April 2012 33. Dhar PK: Virtual cell: computing human skin. Nature India, Mar 2012 32. Dhar PK. Virtual Cell: Making a virtual human liver. Nature India, Feb 2012 31. Dhar PK. Virtual Cell: Making a virtual heart. Nature India, Jan 2012 30. Dhar PK. Virtual cell: Making tiny life forms. Nature India, Dec. 2011 29. Dhar PK. Virtual Cell: How to make one. Nature India, Nov 2011 28. Dhar PK. Virtual Cell. Nature India, Oct. 2011 27. Aswathi BL, AS Nair, A Sivasankaran, PK Dhar (2011): Identification of hub proteins from sequence. Bioinformation 7,163-8 26. Tun K, Menghini M, Dhar PK, Tanaka H, Giuliani A (2011): Why so few drug targets: a mathematical explanation. Current Computer-Aided Drug Design 7, 206-213 25. Dhar PK (2011): A periodic table for biology. Nature India, May 2011. 24. Dhar PK (2011): Finding new laws in biology. Nature India, Mar 2011 23. Krishnan R, Manjaly-Antony LA, PK Dhar (2010): Building momentum for systems and synthetic biology in India. Sys. Synth. Biol. 4, 237-40. 22. Namboodiri S, Verma C, Dhar PK, Giuliani A, Nair AS (2010): Sequence signatures of allosteric proteins towards rational design . Sys. Synth. Biol 2010: 4(4):271-80 21. Dhar PK, A.Giuliani. Laws in Biology: why so few ? Sys. Synth. Biol 2010: 4, 7-13 20. Rao R, K. Tun, Y. Makita, PK Dhar (2009): Amino-acid Residue Association models for large scale protein- protein interaction prediction In Silico Biol 2009: 9, 0015 19. Tun K, Raghuraj Rao, L Swamedham, PK Dhar (2009): Rich can get poor – an evolutionary study of hub proteins. Sys. Synth. Biol. 2009: 2, 75-82 18. Dhar PK (2007): The next step in biology: A periodic table? J. of Biosciences, 2007: 2, 1005-8 17. Dhar PK, R. Weiss (2006): Enabling the new biology of 21st century. Sys. Synth. Biol 1(1), 1-2 16. Tun K, PK Dhar, MC Palumbo, A. Giuliani (2006): Metabolic Pathways Variability and Sequence / Networks Comparisons. BMC Bioinformatics 7, 24 15. Palumbo MC, A Colosimo, K Tun, PK Dhar, A Giuliani (2006): Networks Everywhere? Some general implications of an emergent metaphor. Current Bioinformatics 1, 219-234 14. Mondry A, Z.Wang, P.K.Dhar (2005): Bone and the kidney: A systems biology approach to the molecular mechanisms of renal osteodystrophy . Curr Mol Med 5, 489-496 13. Dhar PK (2005): Systems Biology is all noise. Current Science 88, 1022-23 12. Zhu H, Yinghui Wu, Sui Huang, Yan Sun, Pawan Dhar (2005): Cellular Automata With Object-Oriented Features For Parallel Molecular Network Modeling. IEEE Transactions in NanoBioscience 2005: 4, 141-148 11. Dhar PK, Tan Chee Meng et al (2005): Grid Cellware - The first grid enabled Tool for Modeling And Simulating cellular processes. Bioinformatics 21, 1284-7 10. S. Arjun, Pawan Dhar, Masaru Tomita (2005): E-Cell System : Basic concepts and applications Kluwer Academic Publishers & Landes Biosciences. USA. 09. Zhu H, Sun Yan, G.Rajagopal, A.Mondry, Pawan Dhar (2004): Facilitating arrhythmia simulation: the method of quantitative cellular automata modeling and parallel running. BioMedical Engineering OnLine 3, 29: 1-15 08. Zhu H, Peter Pang, Yan Sun and Pawan Dhar (2004): Asynchronous Adaptive Time Step In Quantitative Cellular Automata Modeling. BMC Bioinformatics 5, 1-7 07. Dhar P (2004): Application of grid technology in systems biology: parameter estimation. IEEE Proceedings, BioGrid, Japan 06. Rizwan A, Arun Krishnan, Pawan Dhar (2004): A Parallel Implementation of Gillespie's Direct Method. Lecture Notes in Computer Science series 3037, 284-291 05. Dhar PK, Zhu Hao, Santosh Mishra (2004): Computational approach to systems biology: from fraction to integration and beyond. IEEE Transactions on Nano-Bioscience 3, 144-152 04. Dhar PK, TC Meng,S Somani, Li Ye, A Sairam, M Chitre, Z Hao, K Sakharkar. Cellware – a new modeling and simulation tool for Computational Systems Biology. Bioinformatics 2004: 20, 1319-1321 Covered by “The Scientist” magazine, July 05, 2004 03. Meng TC, Sandeep Somani, Pawan Dhar (2004) Modeling and simulation of biological systems with stochasticity. In Silico Biology 2004: 4, 0024. 02. Hao Z, Sui Huang, Pawan Dhar (2003): The next step in Systems Biology: Simulating temporo-spatial dynamics of the molecular networks. BioEssays 26, 68-72. 01. Hashimoto K, Sae Seno, Pawan Dhar, M.Tomita (2002): Integrative modeling of gene expression and metabolismin a cell. Artificial Life and Robotics 6: 99-107. PUBLICATIONS IN GENETICS AND MOLECULAR BIOLOGY 26. Manvati S, KC Mangalhar, J Khan, , GL Pathania, S Kaul, M Kaushik, A Arora, PK. Dhar. Deciphering the role of microRNA – A step by step guide. Gene Expression Patterns (accepted) 2017 25. Das P, Dlleepkumar R, AS Krishnan, AS Nair, PK Dhar, Oommen OV. Decahydroquinolines from the venom of a formicinae ant, Oecophylla smaragdina. Toxicon 2014: 92, 50-3. 24. Dhar PK. The dark matter of genome. Nature India, Jan 2013 23. Kumari U, PK Dhar, UM Dhanalekshmi, GK Bhat (2013): Fibroadenoma and breast cancer patients’ lymphocytes sensitivity to gamma rays- An evaluation by micronuclei assay. Annals of Biological Research 4, 148-156. 22. Kumari U, PK Dhar, UM Dhanalekshmi, GK Bhat (2013): Significance of silver stained nucleolar organizer regions in benign breast diseases and breast cancer. Archives of Applied Science Research 5, 60-68. 21. Dhar PK. Will recombinant DNA technology become obsolete? Nature India, Dec 2012 20. Dhar PK. What's ailing our lungs? Nature India, July 2011 19. Dhar PK. Shape me up DNA.Nature India, June 2011 18. Dhar PK. Zincing towards genome engineering. Nature India Jan 2011 17. Dhar PK. 'Promoting' DNA once again. Nature India Dec 2010 16. Dhar PK. The Language of Life. Nature India Oct. 2010 15. Sakharkar KR, Pawan K. Dhar and Vincent T.K. Chow (2004): Genome reduction in prokaryotic obligatory intracellular parasites of humans – a comparative analysis. Int J Syst Evol Microbiol 54, 1937 – 41. 14. Sonoda E, Zhao GY, Kohzaki M, Dhar PK, Kikuchi K, Redon C, Pilch DR, Bonner WM, et al (2007): Collaborative roles of gamma H2AX and Rad51 paralog Xrcc3 in homologous recombinational repair. DNA Repair 6,280-92. 13. Dhar PK (2004): The Cell equator - more than poles apart. Trends in Biotechnology 22, 103-4 12. Dhar PK, E.Sonoda, A.Fujimori, Y.M.Yamashita, S Takeda (2001): Experimental evidence in support of chicken DT40 cell line as a unique model for DNA repair studies. Journal of Environ. Path and Toxicol, USA 20:273-283. 11. Fukushima T, M.Takata, C.Morrison, R.Araki, A.Fujimori, M.Abe, K.Tatsumi, M.Jasin, P.K.Dhar et al (2001): Genetic analysis of the DNA dependent protein kinase reveals an inhibitory role of Ku in late G2 phase DNA double strand break repair. JBC 276 (48), 44413-8. 10. Fujimori A, S.Tachiri, E.Sonoda, L.H.Thompson, Pawan K. Dhar, M.Hiraoka, S.Takeda et al (2001): Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells. EMBO J 20, 5513-5520. 09. Dhar Pawan K, A.Kryscio, C.Streffer (2000): Application of FISH technique in normal, transformed and malignant cell lines using alpha pan centromeric DNA probes. Current Sci 78, 1247-49. 08. Dhar PK (2000): Mammalian cloning – an evolutionary perspective. Current Sci. 78, 102. 07. Dhar PK, Rao TR, Sreekumaran Nair N, Mohan S, Chandra S, Bhat KR, Rao K (2000): Identification of risk factors for specific subsites within the oral and oropharyngeal region—a study of 647 cancer patients. Ind J Cancer 37(2-3),114-22. 06. Dhar P K, Y Kumar (2000): GenSoft 2000 - A new software for diagnosing genetic diseases. Ind J Human Genet 5(1), 67-68. 05. Dhar PK, T.R.Rao, U.Harischandran, K.R.Bhat (1999): Diagnostic importance of nuclear morphometry in oral cancers. Ind J. Orofacial Genetics 2 (2); 15-21. 04. Dhar Pawan K (1999): Oral DNA vaccines – The start of the art. Ind J Orofacial Genet 1, 11-4 03. Dhar Pawan K, S.Devi., et al (1996): Significance of Lymphocyte Sister Chromatid Exchanges in Ovarian Cancer patients . Cancer Genet & Cytogenet 89(2); 105-108. 02. Dhar PK, MR Kumar, S Nayak, et al 91995): A rapid staining and destaining technique for silver nucleolus organizer regions. Biotechnic and Histochemistry. 70(6); 302-30. 01. Bamezai R, Bhattacharya V, Husain SA, Dhar P K (1989): Genetics of non-syndromic cleft lip and palate - A five year study. DAE proceedings on Human Genetics 10, 55-60. BOOKS 11. E-Cell System : Basic concepts and applications Kluwer Academic Publishers & Landes Biosciences. USA. S. Arjun, Pawan Dhar, Masaru Tomita (2005) 10. Textbook of Biochemistry Jay Pee Brothers Medical Publishers, New Delhi, (1998). Vasudevan DM, Sreekumari, S, Dhar Pawan, Bhat PG 9. Human Genetics Jay Pee Brothers Medical Publishers, New Delhi, (1997). Dhar Pawan 8. Latest Concepts in Medical Genetics KMC Press, Manipal, India, (1995) Dhar Pawan CHAPTERS 7. Modeling Spatiotemporal Dynamics of Multicellular signaling Book chapter in: Introduction to Systems Biology Editor: Sandun Choi, Caltech Humana Press, USA, 2007 Hao Zhu, Pawan Dhar 6. Computer Aided Design of Signaling Networks Book chapter in: Information processing and living systems. Vladmir Bajic Eds. World Scientific Press (2005) Zhu Hao, Pawan Dhar 5. Electronic Cell Environments: Combining Gene, Protein and Metabolic Networks Book Chapter in: Complex Systems Science in Biomedicine. Deisboeck TS, Yasha Kresh J, Kepler TB Eds. (2003) Kluwer Academic Publishers, New York. Pawan Dhar, Masaru Tomita 4. E- Cell: Computer simulation of Electronic Cell Book chapter in: Encyclopedia of Molecular cell biology and Molecula Medicine. Robert A Myers Eds.WILEY-VCH Verlag, GmbH & Co (2003) Pawan Dhar, Kouichi Takahashi, Yoichi Nakayama, Masaru Tomita 3. Medical Genetics Questions Exam Master Corporation, Delaware, USA. (Electronic publication), (2000) Dhar Pawan 2. Human Genetics Book chapter in: Textbook of Pedodontics Tandon S Eds. Paras Medical Publishers. Hyderabad., India, (2001) Dhar Pawan 1.Career in Human Genetics Book chapter in: Specialty selection guide. Fact Find Eds. MAHE Publications. Manipal, India (2000) Dhar Pawan |
